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Madabhushi thinks his familiarity with DNA breaks in neurons could assistance illuminate the molecular mechanisms bringing about gene fusions in prostate cancer.
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Likewise, studying DNA mend mechanisms And the way they go awry in prostate most cancers could help know how neuronal functions from the getting old Mind grow to be altered, and advise tips on how to protect them.
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it could seem odd that a researcher from the Office of Psychiatry is working on prostate cancer. But as being a postdoctoral researcher in neuroscience, Madabhushi identified that when neurons are stimulated, as in reaction to new sensory experiences, Additionally they incur DNA breaks at unique destinations inside their genomes.
There's two possibilities: discover a means to decrease the frequency of breaks and modify the development of most cancers, or perturb DNA repair service mechanisms in methods that might kill cancer cells, he claims. “We don’t nonetheless know that's far more promising.”
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